Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

INTRODUCTION: Previous magnetic resonance spectroscopy (MRS) and mass spectroscopy studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a powerful positive prognostic marker in malignant gliomas. Hence, 2HG accumula...

Descripción completa

Detalles Bibliográficos
Autores principales: Natsumeda, Manabu, Igarashi, Hironaka, Nomura, Toshiharu, Ogura, Ryosuke, Tsukamoto, Yoshihiro, Kobayashi, Tsutomu, Aoki, Hiroshi, Okamoto, Kouichirou, Kakita, Akiyoshi, Takahashi, Hitoshi, Nakada, Tsutomu, Fujii, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236810/
https://www.ncbi.nlm.nih.gov/pubmed/25376594
http://dx.doi.org/10.1186/s40478-014-0158-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236810/
https://www.ncbi.nlm.nih.gov/pubmed/25376594
http://dx.doi.org/10.1186/s40478-014-0158-y

Ejemplares similares