Tissue Engineered Scaffolds in Regenerative Medicine

Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic t...

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Autores principales: Hosseinkhani, Mohsen, Mehrabani, Davood, Karimfar, Mohammad Hassan, Bakhtiyari, Salar, Manafi, Amir, Shirazi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society for Plastic Surgeons 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236978/
https://www.ncbi.nlm.nih.gov/pubmed/25489516
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author Hosseinkhani, Mohsen
Mehrabani, Davood
Karimfar, Mohammad Hassan
Bakhtiyari, Salar
Manafi, Amir
Shirazi, Reza
author_facet Hosseinkhani, Mohsen
Mehrabani, Davood
Karimfar, Mohammad Hassan
Bakhtiyari, Salar
Manafi, Amir
Shirazi, Reza
author_sort Hosseinkhani, Mohsen
collection PubMed
description Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications.
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spelling pubmed-42369782014-12-08 Tissue Engineered Scaffolds in Regenerative Medicine Hosseinkhani, Mohsen Mehrabani, Davood Karimfar, Mohammad Hassan Bakhtiyari, Salar Manafi, Amir Shirazi, Reza World J Plast Surg Review Article Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications. Iranian Society for Plastic Surgeons 2014-01 /pmc/articles/PMC4236978/ /pubmed/25489516 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hosseinkhani, Mohsen
Mehrabani, Davood
Karimfar, Mohammad Hassan
Bakhtiyari, Salar
Manafi, Amir
Shirazi, Reza
Tissue Engineered Scaffolds in Regenerative Medicine
title Tissue Engineered Scaffolds in Regenerative Medicine
title_full Tissue Engineered Scaffolds in Regenerative Medicine
title_fullStr Tissue Engineered Scaffolds in Regenerative Medicine
title_full_unstemmed Tissue Engineered Scaffolds in Regenerative Medicine
title_short Tissue Engineered Scaffolds in Regenerative Medicine
title_sort tissue engineered scaffolds in regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236978/
https://www.ncbi.nlm.nih.gov/pubmed/25489516
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