Tissue Engineered Scaffolds in Regenerative Medicine
Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society for Plastic Surgeons
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236978/ https://www.ncbi.nlm.nih.gov/pubmed/25489516 |
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author | Hosseinkhani, Mohsen Mehrabani, Davood Karimfar, Mohammad Hassan Bakhtiyari, Salar Manafi, Amir Shirazi, Reza |
author_facet | Hosseinkhani, Mohsen Mehrabani, Davood Karimfar, Mohammad Hassan Bakhtiyari, Salar Manafi, Amir Shirazi, Reza |
author_sort | Hosseinkhani, Mohsen |
collection | PubMed |
description | Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications. |
format | Online Article Text |
id | pubmed-4236978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Iranian Society for Plastic Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-42369782014-12-08 Tissue Engineered Scaffolds in Regenerative Medicine Hosseinkhani, Mohsen Mehrabani, Davood Karimfar, Mohammad Hassan Bakhtiyari, Salar Manafi, Amir Shirazi, Reza World J Plast Surg Review Article Stem cells are self-renewing cells that can be differentiated into other cell types. Conventional in vitro models for studying stem cells differentiation are usually preformed in two-dimensional (2D) cultures. The design of three-dimensional (3D) in vitro models which ideally are supposed to mimic the in vivo stem cells microenvironment is potentially useful for inducing stem cell derived tissue formation. Biodegradable scaffolds play an important role in creating a 3D environment to induce tissue formation. The application of scaffolding materials together with stem cell technologies are believed to hold enormous potential for tissue regeneration. In this review, we provide an overview of application of tissue engineered scaffolds and stem cells for the development of stem cell-based engineered tissue replacements. In particular, we focus on bone marrow stem cells (BMSCs) and mesenchymal stem cell (MSCs) due to their extensive clinical applications. Iranian Society for Plastic Surgeons 2014-01 /pmc/articles/PMC4236978/ /pubmed/25489516 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hosseinkhani, Mohsen Mehrabani, Davood Karimfar, Mohammad Hassan Bakhtiyari, Salar Manafi, Amir Shirazi, Reza Tissue Engineered Scaffolds in Regenerative Medicine |
title | Tissue Engineered Scaffolds in Regenerative Medicine |
title_full | Tissue Engineered Scaffolds in Regenerative Medicine |
title_fullStr | Tissue Engineered Scaffolds in Regenerative Medicine |
title_full_unstemmed | Tissue Engineered Scaffolds in Regenerative Medicine |
title_short | Tissue Engineered Scaffolds in Regenerative Medicine |
title_sort | tissue engineered scaffolds in regenerative medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236978/ https://www.ncbi.nlm.nih.gov/pubmed/25489516 |
work_keys_str_mv | AT hosseinkhanimohsen tissueengineeredscaffoldsinregenerativemedicine AT mehrabanidavood tissueengineeredscaffoldsinregenerativemedicine AT karimfarmohammadhassan tissueengineeredscaffoldsinregenerativemedicine AT bakhtiyarisalar tissueengineeredscaffoldsinregenerativemedicine AT manafiamir tissueengineeredscaffoldsinregenerativemedicine AT shirazireza tissueengineeredscaffoldsinregenerativemedicine |