Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin

Betulinic acid (BA) is a pentacyclic triterpenoid natural product reported to inhibit cell growth in a variety of cancers. However, the further clinical development of BA got hampered because of poor solubility and pharmacological properties. Interestingly, this molecule offer several hotspots for s...

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Detalles Bibliográficos
Autores principales: Majeed, R, Hamid, A, Sangwan, P L, Chinthakindi, P K, Koul, S, Rayees, S, Singh, G, Mondhe, D M, Mintoo, M J, Singh, S K, Rath, S K, Saxena, A K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237233/
https://www.ncbi.nlm.nih.gov/pubmed/25299784
http://dx.doi.org/10.1038/cddis.2014.387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237233/
https://www.ncbi.nlm.nih.gov/pubmed/25299784
http://dx.doi.org/10.1038/cddis.2014.387

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