Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca(2+) uptake and reactive oxygen species generation

Mcl-1 is an antiapoptotic member of the Bcl-2 family frequently upregulated in non-small cell lung carcinoma (NSCLC). We now report the physiological significance of an interaction between Mcl-1 and the mitochondrial outer membrane-localized voltage-dependent anion channel (VDAC) in NSCLC cell lines...

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Detalles Bibliográficos
Autores principales: Huang, H, Shah, K, Bradbury, N A, Li, C, White, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237246/
https://www.ncbi.nlm.nih.gov/pubmed/25341036
http://dx.doi.org/10.1038/cddis.2014.419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237246/
https://www.ncbi.nlm.nih.gov/pubmed/25341036
http://dx.doi.org/10.1038/cddis.2014.419

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