Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent with cancer cell-selective cell death inducing effect. However, the major limitation in the usage of TRAIL as a chemotherapeutic agent is the development of TRAIL resistance in many cancer types includi...

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Detalles Bibliográficos
Autores principales: Trivedi, R, Maurya, R, Mishra, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237253/
https://www.ncbi.nlm.nih.gov/pubmed/25321472
http://dx.doi.org/10.1038/cddis.2014.429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237253/
https://www.ncbi.nlm.nih.gov/pubmed/25321472
http://dx.doi.org/10.1038/cddis.2014.429

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