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Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

VAPB is a ubiquitously expressed, ER-resident adaptor protein involved in interorganellar lipid exchange, membrane contact site formation, and membrane trafficking. Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates int...

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Detalles Bibliográficos
Autores principales: Genevini, Paola, Papiani, Giulia, Ruggiano, Annamaria, Cantoni, Lavinia, Navone, Francesca, Borgese, Nica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237408/
https://www.ncbi.nlm.nih.gov/pubmed/25409455
http://dx.doi.org/10.1371/journal.pone.0113416