Cargando…

Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

VAPB is a ubiquitously expressed, ER-resident adaptor protein involved in interorganellar lipid exchange, membrane contact site formation, and membrane trafficking. Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Genevini, Paola, Papiani, Giulia, Ruggiano, Annamaria, Cantoni, Lavinia, Navone, Francesca, Borgese, Nica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237408/ https://www.ncbi.nlm.nih.gov/pubmed/25409455 http://dx.doi.org/10.1371/journal.pone.0113416

Ejemplares similares

Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?
por: Borgese, Nica, et al.
Publicado: (2021)

The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis
por: Borgese, Nica, et al.
Publicado: (2021)

Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS
por: Navone, Francesca, et al.
Publicado: (2015)

Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment
por: Kuijpers, Marijn, et al.
Publicado: (2013)

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis
por: Chen, Han-Jou, et al.
Publicado: (2010)

Yeast Models of Amyotrophic Lateral Sclerosis Type 8 Mimic Phenotypes Seen in Mammalian Cells Expressing Mutant VAPB(P56S)
por: Stump, AnnaMari L., et al.
Publicado: (2023)

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis
por: Deivasigamani, Senthilkumar, et al.
Publicado: (2014)

Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis
por: Hartopp, Naomi, et al.
Publicado: (2022)

Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1(G93A) Amyotrophic Lateral Sclerosis
por: Valbuena, Gabriel N., et al.
Publicado: (2019)

Sequestosome 1 Is Part of the Interaction Network of VAPB
por: James, Christina, et al.
Publicado: (2021)

Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43
por: Kitamura, Akira, et al.
Publicado: (2023)

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis
por: Valbuena, Gabriel N., et al.
Publicado: (2015)

Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma
por: Faria Assoni, Amanda, et al.
Publicado: (2023)

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
por: Qiu, Linghua, et al.
Publicado: (2013)

Coexistence of neuronal intranuclear inclusion disease and amyotrophic lateral sclerosis: an autopsy case
por: Sugiyama, Atsuhiko, et al.
Publicado: (2021)

Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis
por: Tan, Rachel H., et al.
Publicado: (2023)

Autophagy dysregulation by mutant fused in sarcoma—implications for amyotrophic lateral sclerosis
por: Soo, K Y, et al.
Publicado: (2015)

Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
por: Conforti, Francesca Luisa, et al.
Publicado: (2006)

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
por: Lai, Chen, et al.
Publicado: (2009)

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis
por: Vehviläinen, Piia, et al.
Publicado: (2014)

Mutant Profilin1 Aggregation in Amyotrophic Lateral Sclerosis: An in Vivo Biochemical Analysis
por: Nekouei, Mina, et al.
Publicado: (2021)

Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral Sclerosis
por: Yamashita, Takenari, et al.
Publicado: (2017)

ER-associated degradation: Protein quality control and beyond
por: Ruggiano, Annamaria, et al.
Publicado: (2014)

Accumulation of Wildtype and ALS-Linked Mutated VAPB Impairs Activity of the Proteasome
por: Moumen, Anice, et al.
Publicado: (2011)

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
por: De Vos, Kurt J., et al.
Publicado: (2012)

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER
por: Costello, Joseph L., et al.
Publicado: (2017)

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy
por: Gomez-Suaga, Patricia, et al.
Publicado: (2017)

Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations
por: Costello, Joseph L., et al.
Publicado: (2017)

VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology
por: Cadoni, Maria Piera L, et al.
Publicado: (2020)

Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis
por: Tan, Rachel H., et al.
Publicado: (2017)

Case report: Adult-onset neuronal intranuclear inclusion disease with an amyotrophic lateral sclerosis phenotype
por: Fujita, Masako, et al.
Publicado: (2022)

Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis
por: De Santis, Riccardo, et al.
Publicado: (2019)

Structural, Stability, Dynamic and Binding Properties of the ALS-Causing T46I Mutant of the hVAPB MSP Domain as Revealed by NMR and MD Simulations
por: Lua, Shixiong, et al.
Publicado: (2011)

Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis
por: Cereda, Cristina, et al.
Publicado: (2013)

Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis
por: De Marco, Giovanni, et al.
Publicado: (2022)

Current Therapeutic Strategies in BRAF-Mutant Metastatic Colorectal Cancer
por: Grassi, Elisa, et al.
Publicado: (2021)

Amyotrophic lateral sclerosis
por: Wijesekera, Lokesh C, et al.
Publicado: (2009)

The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function
por: Silbernagel, Nicole, et al.
Publicado: (2018)

Role of VAPB and vesicular profiles in α‐synuclein aggregates in multiple system atrophy
por: Mori, Fumiaki, et al.
Publicado: (2021)

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis
por: Tokuda, Eiichi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3mmrjjbb34m5vatr338rf2hi11