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Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

VAPB is a ubiquitously expressed, ER-resident adaptor protein involved in interorganellar lipid exchange, membrane contact site formation, and membrane trafficking. Its mutant form, P56S-VAPB, which has been linked to a dominantly inherited form of Amyotrophic Lateral Sclerosis (ALS8), generates int...

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Detalles Bibliográficos
Autores principales:	Genevini, Paola, Papiani, Giulia, Ruggiano, Annamaria, Cantoni, Lavinia, Navone, Francesca, Borgese, Nica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237408/ https://www.ncbi.nlm.nih.gov/pubmed/25409455 http://dx.doi.org/10.1371/journal.pone.0113416

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