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Fine Tuning of Ca(V)1.3 Ca(2+) Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea

Hearing relies on faithful signal transmission by cochlear inner hair cells (IHCs) onto auditory fibres over a wide frequency and intensity range. Exocytosis at IHC ribbon synapses is triggered by Ca(2+) inflow through Ca(V)1.3 (L-type) Ca(2+) channels. We investigated the macroscopic (whole-cell) a...

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Detalles Bibliográficos
Autores principales: Zampini, Valeria, Johnson, Stuart L., Franz, Christoph, Knipper, Marlies, Holley, Matthew C., Magistretti, Jacopo, Russo, Giancarlo, Marcotti, Walter, Masetto, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237458/
https://www.ncbi.nlm.nih.gov/pubmed/25409445
http://dx.doi.org/10.1371/journal.pone.0113750