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Human Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons
[Image: see text] Aldo-keto reductases (AKRs) are promiscuous NAD(P)(H) dependent oxidoreductases implicated in the metabolic activation of polycyclic aromatic hydrocarbons (PAH). These enzymes catalyze the oxidation of non-K-region trans-dihydrodiols to the corresponding o-quinones with the concomi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237494/ https://www.ncbi.nlm.nih.gov/pubmed/25279998 http://dx.doi.org/10.1021/tx500298n |