Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences

BACKGROUND: Polyglutamine (polyQ) repeat expansion within coding sequence of a soluble protein is responsible for eight autosomal-dominant genetic neurodegenerative disorders. These disorders affect cerebellum, striatum, basal ganglia and other brain regions. The pathogenic polyQ-expansion threshold...

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Detalles Bibliográficos
Autor principal: Kim, Meewhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237751/
https://www.ncbi.nlm.nih.gov/pubmed/25377768
http://dx.doi.org/10.1186/1750-1326-9-45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237751/
https://www.ncbi.nlm.nih.gov/pubmed/25377768
http://dx.doi.org/10.1186/1750-1326-9-45

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