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Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences
BACKGROUND: Polyglutamine (polyQ) repeat expansion within coding sequence of a soluble protein is responsible for eight autosomal-dominant genetic neurodegenerative disorders. These disorders affect cerebellum, striatum, basal ganglia and other brain regions. The pathogenic polyQ-expansion threshold...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237751/ https://www.ncbi.nlm.nih.gov/pubmed/25377768 http://dx.doi.org/10.1186/1750-1326-9-45 |