Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G(2) checkpoint and suppression of homologous recombination repair

BACKGROUND: Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we evaluated the radiosensitizaion potential of YM155 in human esophageal squamous...

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Detalles Bibliográficos
Autores principales: Qin, Qin, Cheng, Hongyan, Lu, Jing, Zhan, Liangliang, Zheng, Jianchao, Cai, Jing, Yang, Xi, Xu, Liping, Zhu, Hongcheng, Zhang, Chi, Liu, Jia, Ma, Jianxin, Zhang, Xizhi, Dai, Shengbin, Sun, Xinchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237864/
https://www.ncbi.nlm.nih.gov/pubmed/25139395
http://dx.doi.org/10.1186/s13045-014-0062-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237864/
https://www.ncbi.nlm.nih.gov/pubmed/25139395
http://dx.doi.org/10.1186/s13045-014-0062-8

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