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Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension

Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and progression of systemic sclerosis-associated pulmona...

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Detalles Bibliográficos
Autores principales: Boin, Francesco, Erre, Gian Luca, Posadino, Anna Maria, Cossu, Annalisa, Giordo, Roberta, Spinetti, Gaia, Passiu, Giuseppe, Emanueli, Costanza, Pintus, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237898/
https://www.ncbi.nlm.nih.gov/pubmed/25085432
http://dx.doi.org/10.1186/s13023-014-0123-7