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Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension
Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and progression of systemic sclerosis-associated pulmona...
Autores principales: | Boin, Francesco, Erre, Gian Luca, Posadino, Anna Maria, Cossu, Annalisa, Giordo, Roberta, Spinetti, Gaia, Passiu, Giuseppe, Emanueli, Costanza, Pintus, Gianfranco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237898/ https://www.ncbi.nlm.nih.gov/pubmed/25085432 http://dx.doi.org/10.1186/s13023-014-0123-7 |
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