Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells

Insulin resistance is central to diabetes and metabolic syndrome. To define the consequences of genetic insulin resistance distinct from those secondary to cellular differentiation or in vivo regulation, we generated induced pluripotent stem cells (iPSCs) from individuals with insulin receptor mutat...

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Detalles Bibliográficos
Autores principales: Iovino, Salvatore, Burkart, Alison M., Kriauciunas, Kristina, Warren, Laura, Hughes, Katelyn J., Molla, Michael, Lee, Youn-Kyoung, Patti, Mary-Elizabeth, Kahn, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238001/
https://www.ncbi.nlm.nih.gov/pubmed/25059784
http://dx.doi.org/10.2337/db14-0109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238001/
https://www.ncbi.nlm.nih.gov/pubmed/25059784
http://dx.doi.org/10.2337/db14-0109

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