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gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains

The modification of proteins with polyubiquitin chains alters their stability, localization and activity, thus regulating various aspects of cellular functions in eukaryotic cells. The ER quality control protein E3 gp78 catalyzes Lys48-linked polyubiquitin-chain- assembly on the Ube2g2 active site a...

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Detalles Bibliográficos
Autores principales: Liu, Weixiao, Shang, Yongliang, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238023/
https://www.ncbi.nlm.nih.gov/pubmed/25409783
http://dx.doi.org/10.1038/srep07138