MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and...

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Detalles Bibliográficos
Autores principales: Landon, Ari L., Muniandy, Parameswary A., Shetty, Amol C., Lehrmann, Elin, Volpon, Laurent, Houng, Simone, Zhang, Yongqing, Dai, Bojie, Peroutka, Raymond, Mazan-Mamczarz, Krystyna, Steinhardt, James, Mahurkar, Anup, Becker, Kevin G., Borden, Katherine L., Gartenhaus, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238046/
https://www.ncbi.nlm.nih.gov/pubmed/25403230
http://dx.doi.org/10.1038/ncomms6413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238046/
https://www.ncbi.nlm.nih.gov/pubmed/25403230
http://dx.doi.org/10.1038/ncomms6413

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