Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on...

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Detalles Bibliográficos
Autores principales: Zingales, Bianca, Miles, Michael A, Moraes, Carolina B, Luquetti, Alejandro, Guhl, Felipe, Schijman, Alejandro G, Ribeiro, Isabela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Materias:
Readers' Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238778/
https://www.ncbi.nlm.nih.gov/pubmed/25317712
http://dx.doi.org/10.1590/0074-0276140156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238778/
https://www.ncbi.nlm.nih.gov/pubmed/25317712
http://dx.doi.org/10.1590/0074-0276140156

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