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Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on...

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Detalles Bibliográficos
Autores principales:	Zingales, Bianca, Miles, Michael A, Moraes, Carolina B, Luquetti, Alejandro, Guhl, Felipe, Schijman, Alejandro G, Ribeiro, Isabela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2014
Materias:	Readers' Opinion
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238778/ https://www.ncbi.nlm.nih.gov/pubmed/25317712 http://dx.doi.org/10.1590/0074-0276140156

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