The impact of co-administration of ketoconazole and rifampicin on the pharmacokinetics of apremilast in healthy volunteers

AIMS: Two clinical studies were conducted to determine possible drug−drug interactions between apremilast and a strong CYP3A4 inhibitor, ketoconazole, or a potent CYP3A4 inducer, rifampicin. The main objectives of these two studies were to evaluate the impact of multiple doses of ketoconazole on the...

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Detalles Bibliográficos
Autores principales: Liu, Yong, Zhou, Simon, Wan, Yuntao, Wu, Anfan, Palmisano, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238785/
https://www.ncbi.nlm.nih.gov/pubmed/24962564
http://dx.doi.org/10.1111/bcp.12448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238785/
https://www.ncbi.nlm.nih.gov/pubmed/24962564
http://dx.doi.org/10.1111/bcp.12448

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