Protein kinase C and P2Y(12) take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets

BACKGROUND: Rapamycin, an inhibitor of mammalian target of rapamycin complex-1 (mTORC1), reduces platelet spreading, thrombus stability, and clot retraction. Despite an important role of mTORC1 in platelet function, little is known about how it is regulated. The objective of this study was to determ...

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Detalles Bibliográficos
Autores principales: Moore, S F, Hunter, R W, Hers, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Platelets
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238809/
https://www.ncbi.nlm.nih.gov/pubmed/24612393
http://dx.doi.org/10.1111/jth.12552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238809/
https://www.ncbi.nlm.nih.gov/pubmed/24612393
http://dx.doi.org/10.1111/jth.12552

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