The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase) is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 DNA helicase. DDK is overexpressed in many tumor cells and is an emerging chemotherapeutic target since DDK inhibition causes apoptosis of diverse cancer c...

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Detalles Bibliográficos
Autores principales: Sasi, Nanda Kumar, Tiwari, Kanchan, Soon, Fen-Fen, Bonte, Dorine, Wang, Tong, Melcher, Karsten, Xu, H. Eric, Weinreich, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239038/
https://www.ncbi.nlm.nih.gov/pubmed/25412417
http://dx.doi.org/10.1371/journal.pone.0113300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239038/
https://www.ncbi.nlm.nih.gov/pubmed/25412417
http://dx.doi.org/10.1371/journal.pone.0113300

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