Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in att...

Descripción completa

Detalles Bibliográficos
Autores principales: Martin, Tamara P., Hortigon-Vinagre, Maria P., Findlay, Jane E., Elliott, Christina, Currie, Susan, Baillie, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239479/
https://www.ncbi.nlm.nih.gov/pubmed/25426411
http://dx.doi.org/10.1016/j.fob.2014.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239479/
https://www.ncbi.nlm.nih.gov/pubmed/25426411
http://dx.doi.org/10.1016/j.fob.2014.10.011

Ejemplares similares