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Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy

Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20–phosphodiesterase 4D (PDE4D) complex results in att...

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Detalles Bibliográficos
Autores principales:	Martin, Tamara P., Hortigon-Vinagre, Maria P., Findlay, Jane E., Elliott, Christina, Currie, Susan, Baillie, George S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239479/ https://www.ncbi.nlm.nih.gov/pubmed/25426411 http://dx.doi.org/10.1016/j.fob.2014.10.011

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