Global human frequencies of predicted nuclear pathogenic variants and the role played by protein hydrophobicity in pathogenicity potential

Mitochondrial proteins are coded by nuclear (nDNA) and mitochondrial (mtDNA) genes, implying a complex cross-talk between the two genomes. Here we investigated the diversity displayed in 104 nuclear-coded mitochondrial proteins from 1,092 individuals from the 1000 Genomes dataset, in order to evalua...

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Detalles Bibliográficos
Autores principales: Pereira, Luísa, Soares, Pedro, Triska, Petr, Rito, Teresa, van der Waerden, Agnes, Li, Biao, Radivojac, Predrag, Samuels, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239565/
https://www.ncbi.nlm.nih.gov/pubmed/25412673
http://dx.doi.org/10.1038/srep07155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239565/
https://www.ncbi.nlm.nih.gov/pubmed/25412673
http://dx.doi.org/10.1038/srep07155

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