Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G(i)-proteins in murine BV-2 microglia cells

BACKGROUND: Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) was shown to suppress microglia activation and decrease the release of associated pro-inflammatory mediators. In contrast, the consequences of mGluR5 inhibition are less well understoo...

Descripción completa

Detalles Bibliográficos
Autores principales: Chantong, Boonrat, Kratschmar, Denise V, Lister, Adam, Odermatt, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240888/
https://www.ncbi.nlm.nih.gov/pubmed/25407356
http://dx.doi.org/10.1186/s12974-014-0190-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240888/
https://www.ncbi.nlm.nih.gov/pubmed/25407356
http://dx.doi.org/10.1186/s12974-014-0190-7

Ejemplares similares