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Inhibition of metabotropic glutamate receptor 5 induces cellular stress through pertussis toxin-sensitive G(i)-proteins in murine BV-2 microglia cells
BACKGROUND: Activation of metabotropic glutamate receptor 5 (mGluR5) by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) was shown to suppress microglia activation and decrease the release of associated pro-inflammatory mediators. In contrast, the consequences of mGluR5 inhibition are less well understoo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240888/ https://www.ncbi.nlm.nih.gov/pubmed/25407356 http://dx.doi.org/10.1186/s12974-014-0190-7 |