Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

The recognition of cancer cells by T cells can impact upon prognosis and be exploited for immunotherapeutic approaches. This recognition depends on the specific interaction between antigens displayed on the surface of cancer cells and the T cell receptor (TCR), which is generated by somatic rearrang...

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Detalles Bibliográficos
Autores principales: Gerlinger, Marco, Quezada, Sergio A, Peggs, Karl S, Furness, Andrew JS, Fisher, Rosalie, Marafioti, Teresa, Shende, Vishvesh H, McGranahan, Nicholas, Rowan, Andrew J, Hazell, Steven, Hamm, David, Robins, Harlan S, Pickering, Lisa, Gore, Martin, Nicol, David L, Larkin, James, Swanton, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2013
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241038/
https://www.ncbi.nlm.nih.gov/pubmed/24122851
http://dx.doi.org/10.1002/path.4284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241038/
https://www.ncbi.nlm.nih.gov/pubmed/24122851
http://dx.doi.org/10.1002/path.4284

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