Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

[Image: see text] The stress-inducible mammalian heat shock protein 70 (HSP70) and its bacterial orthologue DnaK are highly conserved nucleotide binding molecular chaperones. They represent critical regulators of cellular proteostasis, especially during conditions of enhanced stress. Cancer cells re...

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Detalles Bibliográficos
Autores principales: Leu, Julia I-Ju, Zhang, Pingfeng, Murphy, Maureen E., Marmorstein, Ronen, George, Donna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241170/
https://www.ncbi.nlm.nih.gov/pubmed/25148104
http://dx.doi.org/10.1021/cb500236y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241170/
https://www.ncbi.nlm.nih.gov/pubmed/25148104
http://dx.doi.org/10.1021/cb500236y

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