The Influence of Drug Physical State on the Dissolution Enhancement of Solid Dispersions Prepared Via Hot-Melt Extrusion: A Case Study Using Olanzapine

In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus® (SLP)]. In particular, we examine...

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Detalles Bibliográficos
Autores principales: Pina, Maria Fátima, Zhao, Min, Pinto, João F, Sousa, João J, Craig, Duncan Q M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Pharmaceutics, Drug Delivery and Pharmaceutical Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241582/
https://www.ncbi.nlm.nih.gov/pubmed/24765654
http://dx.doi.org/10.1002/jps.23894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241582/
https://www.ncbi.nlm.nih.gov/pubmed/24765654
http://dx.doi.org/10.1002/jps.23894

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