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Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain

OBJECTIVE: The mechanism of action of anti-B cell therapy in multiple sclerosis (MS) is not fully understood. Here, we compared the effect of anti-CD20 therapy on microglial activation in two distinct focal rat models of MS. METHODS: The effect of anti-CD20 therapy on lesion formation and extralesio...

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Detalles Bibliográficos
Autores principales: Anthony, Daniel C, Dickens, Alex M, Seneca, Nicholas, Couch, Yvonne, Campbell, Sandra, Checa, Begona, Kersemans, Veerle, Warren, Edward A, Tredwell, Matthew, Sibson, Nicola R, Gouverneur, Veronique, Leppert, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241793/
https://www.ncbi.nlm.nih.gov/pubmed/25493280
http://dx.doi.org/10.1002/acn3.94