Cargando…

Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis

Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-58 deficiency in murine macrophages, we generated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goeritzer, Madeleine, Schlager, Stefanie, Radovic, Branislav, Madreiter, Corina T., Rainer, Silvia, Thomas, Gwynneth, Lord, Caleb C., Sacks, Jessica, Brown, Amanda L., Vujic, Nemanja, Obrowsky, Sascha, Sachdev, Vinay, Kolb, Dagmar, Chandak, Prakash G., Graier, Wolfgang F., Sattler, Wolfgang, Brown, J. Mark, Kratky, Dagmar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242449/ https://www.ncbi.nlm.nih.gov/pubmed/25316883 http://dx.doi.org/10.1194/jlr.M052613

Ejemplares similares

ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes
por: Korbelius, Melanie, et al.
Publicado: (2019)

Active autophagy but not lipophagy in macrophages with defective lipolysis
por: Goeritzer, Madeleine, et al.
Publicado: (2015)

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice
por: Vujic, Nemanja, et al.
Publicado: (2015)

Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis()
por: Kratky, Dagmar, et al.
Publicado: (2014)

Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo
por: Goeritzer, Madeleine, et al.
Publicado: (2022)

Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice
por: Radović, Branislav, et al.
Publicado: (2016)

Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE−/− mice
por: Vujic, Nemanja, et al.
Publicado: (2017)

ATG7 is dispensable for LC3–PE conjugation in thioglycolate-elicited mouse peritoneal macrophages
por: Vujić, Nemanja, et al.
Publicado: (2021)

The lipase cofactor CGI58 controls placental lipolysis
por: Guerrero-Santoro, Jennifer, et al.
Publicado: (2023)

Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase
por: Sachdev, Vinay, et al.
Publicado: (2021)

Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice
por: Goeritzer, Madeleine, et al.
Publicado: (2023)

Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden
por: Vujić, Nemanja, et al.
Publicado: (2020)

Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages
por: Schlager, Stefanie, et al.
Publicado: (2017)

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis
por: Schlager, Stefanie, et al.
Publicado: (2015)

Association between the levels of CGI-58 and lipoprotein lipase in the placenta of patients with preeclampsia
por: Dong, Jianxin, et al.
Publicado: (2021)

Distinct roles for α-β hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling
por: Lord, Caleb C., et al.
Publicado: (2012)

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
por: Lord, Caleb C., et al.
Publicado: (2012)

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling
por: Obrowsky, Sascha, et al.
Publicado: (2013)

Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation
por: Leopold, Christina, et al.
Publicado: (2019)

Lysophosphatidic Acid Receptor 5 (LPA(5)) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro
por: Joshi, Lisha, et al.
Publicado: (2022)

Endothelial lipase increases eNOS activating capacity of high-density lipoprotein
por: Radulović, Snježana, et al.
Publicado: (2020)

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
por: Chandak, Prakash G., et al.
Publicado: (2010)

Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases
por: Schittmayer, Matthias, et al.
Publicado: (2020)

Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro
por: Goeritzer, Madeleine, et al.
Publicado: (2020)

Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice
por: Obrowsky, Sascha, et al.
Publicado: (2012)

Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis(☆)
por: Korbelius, Melanie, et al.
Publicado: (2022)

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase
por: Bradić, Ivan, et al.
Publicado: (2023)

Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice
por: Vujic, Nemanja, et al.
Publicado: (2016)

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages
por: Aflaki, Elma, et al.
Publicado: (2011)

Reassessing the Potential Activities of Plant CGI-58 Protein
por: Khatib, Abdallah, et al.
Publicado: (2016)

Clinicalpathologic and Prognostic Significance of CGI-58 in Endometrial Cancer
por: Shi, Zhengzheng, et al.
Publicado: (2021)

Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
por: Bradić, Ivan, et al.
Publicado: (2022)

Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice
por: Chandak, Prakash G., et al.
Publicado: (2011)

Intestinal Cgi-58 Deficiency Reduces Postprandial Lipid Absorption
por: Xie, Ping, et al.
Publicado: (2014)

Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis
por: Hofer, Dina C., et al.
Publicado: (2017)

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation
por: Grond, Susanne, et al.
Publicado: (2016)

PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice
por: Wang, Yang, et al.
Publicado: (2019)

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
por: Plastira, Ioanna, et al.
Publicado: (2016)

Improved Stability of Human CGI-58 Induced by Phosphomimetic S237E Mutation
por: Llamas-García, Miriam Livier, et al.
Publicado: (2022)

MiR-206 is expressed in pancreatic islets and regulates glucokinase activity
por: Vinod, Manjula, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jf2dqg47ktqlamo9demah5ef26