Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2

During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2. To study the NPC2-mediated intervesicular cholest...

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Detalles Bibliográficos
Autores principales: Oninla, Vincent O., Breiden, Bernadette, Babalola, Jonathan O., Sandhoff, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242453/
https://www.ncbi.nlm.nih.gov/pubmed/25339683
http://dx.doi.org/10.1194/jlr.M054528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242453/
https://www.ncbi.nlm.nih.gov/pubmed/25339683
http://dx.doi.org/10.1194/jlr.M054528

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