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Canonical Notch signalling is inactive in urothelial carcinoma

BACKGROUND: Notch signalling regulates cell fate in most tissues, promoting precursor cell proliferation in some, but differentiation in others. Accordingly, downregulation or overactivity variously contributes to cancer development. So far, little is known about Notch pathway activity and function...

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Detalles Bibliográficos
Autores principales: Greife, Annemarie, Jankowiak, Silvia, Steinbring, Jochen, Nikpour, Parvaneh, Niegisch, Günter, Hoffmann, Michèle J, Schulz, Wolfgang A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242495/
https://www.ncbi.nlm.nih.gov/pubmed/25167871
http://dx.doi.org/10.1186/1471-2407-14-628