Attrition of T-Cell Functions and Simultaneous Upregulation of Inhibitory Markers Correspond with the Waning of BCG-Induced Protection against Tuberculosis in Mice

Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live attenuated vaccine. However, the correlates of protection and waning of its immunity against tuberculosis is poorly understood. In this study, we correlated the longitudinal changes in the magnitude and functional quality...

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Detalles Bibliográficos
Autores principales: Nandakumar, Subhadra, Kannanganat, Sunil, Posey, James E., Amara, Rama Rao, Sable, Suraj B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242676/
https://www.ncbi.nlm.nih.gov/pubmed/25419982
http://dx.doi.org/10.1371/journal.pone.0113951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242676/
https://www.ncbi.nlm.nih.gov/pubmed/25419982
http://dx.doi.org/10.1371/journal.pone.0113951

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