Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration

Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over remain elusive. In this paper, we study Drosophila melanogaster lacking active TBC1D24/Skywalker (Sky), a protein that in hu...

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Detalles Bibliográficos
Autores principales: Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R., Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://www.ncbi.nlm.nih.gov/pubmed/25422373
http://dx.doi.org/10.1083/jcb.201406026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242831/
https://www.ncbi.nlm.nih.gov/pubmed/25422373
http://dx.doi.org/10.1083/jcb.201406026

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