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Visualization of genetic disease-phenotype similarities by multiple maps t-SNE with Laplacian regularization

BACKGROUND: From a phenotypic standpoint, certain types of diseases may prove to be difficult to accurately diagnose, due to specific combinations of confounding symptoms. Referred to as phenotypic overlap, these sets of disease-related symptoms suggest shared pathophysiological mechanisms. Few atte...

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Detalles Bibliográficos
Autores principales: Xu, Weiwei, Jiang, Xingpeng, Hu, Xiaohua, Li, Guangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243097/
https://www.ncbi.nlm.nih.gov/pubmed/25350393
http://dx.doi.org/10.1186/1755-8794-7-S2-S1