The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

Ubiquitin-specific protease USP4 is emerging as an important regulator of cellular pathways, including the TGF-β response, NF-κB signalling and splicing, with possible roles in cancer. Here we show that USP4 has its catalytic triad arranged in a productive conformation. Nevertheless, it requires its...

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Detalles Bibliográficos
Autores principales: Clerici, Marcello, Luna-Vargas, Mark P. A., Faesen, Alex C., Sixma, Titia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243247/
https://www.ncbi.nlm.nih.gov/pubmed/25404403
http://dx.doi.org/10.1038/ncomms6399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243247/
https://www.ncbi.nlm.nih.gov/pubmed/25404403
http://dx.doi.org/10.1038/ncomms6399

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