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CNS axon regeneration inhibitors stimulate an immediate early gene response via MAP kinase-SRF signaling

BACKGROUND: CNS axon regeneration inhibitors such as Nogo and CSPGs (Chondroitin Sulfate Proteoglycans) are major extrinsic factors limiting outgrowth of severed nerve fibers. However, knowledge on intracellular signaling cascades and gene expression programs activated by these inhibitors in neurons...

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Detalles Bibliográficos
Autores principales: Stern, Sina, Knöll, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243276/
https://www.ncbi.nlm.nih.gov/pubmed/25406759
http://dx.doi.org/10.1186/s13041-014-0086-6