Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model

BACKGROUND: Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma. The attenuation of PI3-kinase/AKT signaling will be effective in regulating the tumorigenic phenotypes of the glioma cells. METHODS: Glioma cells derived fro...

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Detalles Bibliográficos
Autores principales: Singh, Alok R, Joshi, Shweta, George, Elizabeth, Durden, Donald L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243316/
https://www.ncbi.nlm.nih.gov/pubmed/25425962
http://dx.doi.org/10.1186/s12935-014-0105-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243316/
https://www.ncbi.nlm.nih.gov/pubmed/25425962
http://dx.doi.org/10.1186/s12935-014-0105-9

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