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Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model

BACKGROUND: Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma. The attenuation of PI3-kinase/AKT signaling will be effective in regulating the tumorigenic phenotypes of the glioma cells. METHODS: Glioma cells derived fro...

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Detalles Bibliográficos
Autores principales:	Singh, Alok R, Joshi, Shweta, George, Elizabeth, Durden, Donald L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243316/ https://www.ncbi.nlm.nih.gov/pubmed/25425962 http://dx.doi.org/10.1186/s12935-014-0105-9

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