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CMV-specific T cell isolation from G-CSF mobilized peripheral blood: depletion of myeloid progenitors eliminates non-specific binding of MHC-multimers

BACKGROUND: Cytomegalovirus (CMV)-specific T cell infusion to immunocompromised patients following allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is able to induce a successful anti-viral response. These cells have classically been manufactured from steady-state apheresis samples col...

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Detalles Bibliográficos
Autores principales: Beloki, Lorea, Ciaurriz, Miriam, Mansilla, Cristina, Zabalza, Amaya, Perez-Valderrama, Estela, Samuel, Edward R, Lowdell, Mark W, Ramirez, Natalia, Olavarria, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243324/
https://www.ncbi.nlm.nih.gov/pubmed/25406933
http://dx.doi.org/10.1186/s12967-014-0317-8