Mechanistic Insight into the Interaction of BLM helicase with Intra-strand G-quadruplex Structures

Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strand...

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Detalles Bibliográficos
Autores principales: Chatterjee, Sujoy, Zagelbaum, Jennifer, Savitsky, Pavel, Sturzenegger, Andreas, Huttner, Diana, Janscak, Pavel, Hickson, Ian D, Gilaedi, Opher, Rothenberg, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243535/
https://www.ncbi.nlm.nih.gov/pubmed/25418155
http://dx.doi.org/10.1038/ncomms6556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243535/
https://www.ncbi.nlm.nih.gov/pubmed/25418155
http://dx.doi.org/10.1038/ncomms6556

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