Impact of M36I polymorphism on the interaction of HIV-1 protease with its substrates: insights from molecular dynamics

BACKGROUND: Over the last decades, a vast structural knowledge has been gathered on the HIV-1 protease (PR). Noticeably, most of the studies focused the B-subtype, which has the highest prevalence in developed countries. Accordingly, currently available anti-HIV drugs target this subtype, with consi...

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Detalles Bibliográficos
Autores principales: Costa, Mauricio GS, Benetti-Barbosa, Técio G, Desdouits, Nathan, Blondel, Arnaud, Bisch, Paulo M, Pascutti, Pedro G, Batista, Paulo R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243740/
https://www.ncbi.nlm.nih.gov/pubmed/25573486
http://dx.doi.org/10.1186/1471-2164-15-S7-S5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243740/
https://www.ncbi.nlm.nih.gov/pubmed/25573486
http://dx.doi.org/10.1186/1471-2164-15-S7-S5

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