Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling

AIMS: The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models. METHODS: Data were obtained from 242 patients with 3100 tacrolimus whole blood concentrations. Ext...

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Detalles Bibliográficos
Autores principales: Størset, Elisabet, Holford, Nick, Hennig, Stefanie, Bergmann, Troels K, Bergan, Stein, Bremer, Sara, Åsberg, Anders, Midtvedt, Karsten, Staatz, Christine E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243902/
https://www.ncbi.nlm.nih.gov/pubmed/25279405
http://dx.doi.org/10.1111/bcp.12361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243902/
https://www.ncbi.nlm.nih.gov/pubmed/25279405
http://dx.doi.org/10.1111/bcp.12361

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