Cargando…

A high-resolution structure of the EF-hand domain of human polycystin-2

Autosomal dominant polycystic kidney disease (ADPKD) affects over 1:1000 of the worldwide population and is caused by mutations in two genes, PKD1 and PKD2. PKD2 encodes a 968-amino acid membrane spanning protein, Polycystin-2 (PC-2), which is a member of the TRP ion channel family. The C-terminal c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Allen, Mark D, Qamar, Seema, Vadivelu, Murali K, Sandford, Richard N, Bycroft, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244000/ https://www.ncbi.nlm.nih.gov/pubmed/24990821 http://dx.doi.org/10.1002/pro.2513

Ejemplares similares

High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1
por: Jacobsen, Julian O. B., et al.
Publicado: (2016)

Disrupting polycystin-2 EF hand Ca(2+) affinity does not alter channel function or contribute to polycystic kidney disease
por: Vien, Thuy N., et al.
Publicado: (2020)

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes
por: Giamarchi, Aurélie, et al.
Publicado: (2010)

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex
por: Wang, Zhifei, et al.
Publicado: (2019)

Polycystins and Mechanotransduction in Human Disease
por: Gargalionis, Antonios N., et al.
Publicado: (2019)

Carboxy Terminal Tail of Polycystin-1 Regulates Localization of TSC2 to Repress mTOR
por: Dere, Ruhee, et al.
Publicado: (2010)

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein–protein interactions
por: Allen, Mark D., et al.
Publicado: (2020)

The structure of the FYR domain of transforming growth factor beta regulator 1
por: García-Alai, María M, et al.
Publicado: (2010)

A polycystin-centric view of cyst formation and disease: the polycystins revisited
por: Ong, Albert CM, et al.
Publicado: (2015)

Role of the EF-hand and coiled-coil domains of human Rab44 in localisation and organelle formation
por: Ogawa, Kohei, et al.
Publicado: (2020)

Polycystins and mechanotransduction in bone
por: Gargalionis, Antonios N., et al.
Publicado: (2017)

Polycystins in Colorectal Cancer
por: Gargalionis, Antonios N., et al.
Publicado: (2018)

Two Structural Motifs within Canonical EF-Hand Calcium-Binding Domains Identify Five Different Classes of Calcium Buffers and Sensors
por: Denessiouk, Konstantin, et al.
Publicado: (2014)

Identification and Functional Characterization of an N-terminal Oligomerization Domain for Polycystin-2
por: Feng, Shuang, et al.
Publicado: (2008)

Structural Interaction and Functional Regulation of Polycystin-2 by Filamin
por: Wang, Qian, et al.
Publicado: (2012)

A novel 9 kDa phosphoprotein is a component of the primary cilium and interacts with polycystin-1
por: Osborn, DPS, et al.
Publicado: (2012)

Polycystins, ADPKD, and Cardiovascular Disease
por: Kuo, Ivana Y., et al.
Publicado: (2019)

Polycystins, mechanotransduction and cancer development
por: Papavassiliou, Kostas A., et al.
Publicado: (2022)

Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain
por: Vien, Thuy N., et al.
Publicado: (2020)

Decoding the Pathophysiology of HFpEF With High-Resolution Phenotyping
por: Houstis, Nicholas E.
Publicado: (2020)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
por: MacKay, Charles E, et al.
Publicado: (2022)

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1)
por: Lea, Wendy A., et al.
Publicado: (2023)

EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish
por: Barrodia, Praveen, et al.
Publicado: (2018)

Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway
por: Tang, Yan, et al.
Publicado: (2017)

Polycystins and cellular Ca(2+) signaling
por: Mekahli, D., et al.
Publicado: (2012)

Polycystin-2 Associates With Malignancy in Meningiomas
por: Assimakopoulou, Martha, et al.
Publicado: (2023)

Energetic landscape of polycystin channel gating
por: Ng, Leo CT, et al.
Publicado: (2023)

Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains
por: Forman, Julia R., et al.
Publicado: (2009)

Analysis of EF-hand-containing proteins in Arabidopsis
por: Day, Irene S, et al.
Publicado: (2002)

Polycystin-1 Surface Localization Is Stimulated by Polycystin-2 and Cleavage at the G Protein-coupled Receptor Proteolytic Site
por: Chapin, Hannah C., et al.
Publicado: (2010)

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis
por: Allen, Mark D., et al.
Publicado: (2015)

Cryo-EM structure of the polycystin 2-l1 ion channel
por: Hulse, Raymond E, et al.
Publicado: (2018)

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2
por: Teufel, Daniel P., et al.
Publicado: (2009)

Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) Domains
por: Ma, Liang, et al.
Publicado: (2009)

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains
por: Yamamoto, Tatsuya, et al.
Publicado: (2014)

Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2
por: Wang, Qinrui, et al.
Publicado: (2020)

Identification of Polycystin-2 and CFTR common targets
por: Roxo-Rosa, M, et al.
Publicado: (2015)

Regulation of Polycystin-1 Function by Calmodulin Binding
por: Doerr, Nicholas, et al.
Publicado: (2016)

The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination
por: Zhang, Wei, et al.
Publicado: (2020)

Analysis of the polycystin complex (PCC) in human urinary exosome–like vesicles (ELVs)
por: Lea, Wendy A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ig2pui83hrnfmuhs02ttq799i0