Valsartan independent of AT(1) receptor inhibits tissue factor, TLR-2 and-4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions

Patients suffering from diabetes mellitus (DM) are at a severe risk of atherothrombosis. Early growth response (Egr)-1 is well characterized as a central mediator in vascular pathophysiology. We tested whether valsartan independent of Ang II type 1 receptor (AT(1)R) can reduce tissue factor (TF) and...

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Detalles Bibliográficos
Autores principales: Ha, Yu Mi, Park, Eun Jung, Kang, Young Jin, Park, Sang Won, Kim, Hye Jung, Chang, Ki Churl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244018/
https://www.ncbi.nlm.nih.gov/pubmed/25109475
http://dx.doi.org/10.1111/jcmm.12354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244018/
https://www.ncbi.nlm.nih.gov/pubmed/25109475
http://dx.doi.org/10.1111/jcmm.12354

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