The Insulin/IGF Signaling Regulators Cytohesin/GRP-1 and PIP5K/PPK-1 Modulate Susceptibility to Excitotoxicity in C. elegans

During ischemic stroke, malfunction of excitatory amino acid transporters and reduced synaptic clearance causes accumulation of Glutamate (Glu) and excessive stimulation of postsynaptic neurons, which can lead to their degeneration by excitotoxicity. The balance between cell death-promoting (neuroto...

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Detalles Bibliográficos
Autores principales: Tehrani, Nazila, Del Rosario, John, Dominguez, Moises, Kalb, Robert, Mano, Itzhak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244091/
https://www.ncbi.nlm.nih.gov/pubmed/25422944
http://dx.doi.org/10.1371/journal.pone.0113060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244091/
https://www.ncbi.nlm.nih.gov/pubmed/25422944
http://dx.doi.org/10.1371/journal.pone.0113060

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