C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway

OBJECTIVE: Diabetic nephropathy (DN) is a serious complication for patients with diabetes mellitus (DM). Emerging evidence suggests that complement C3a is involved in the progression of DN. The aim of this study was to investigate the effect of C3a Receptor Agonist (C3aRA) on DN and its potential me...

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Detalles Bibliográficos
Autores principales: Li, Ling, Yin, Qinghua, Tang, Xi, Bai, Lin, Zhang, Jie, Gou, Shenju, Zhu, Hongping, Cheng, Jingqiu, Fu, Ping, Liu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244104/
https://www.ncbi.nlm.nih.gov/pubmed/25422985
http://dx.doi.org/10.1371/journal.pone.0113639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244104/
https://www.ncbi.nlm.nih.gov/pubmed/25422985
http://dx.doi.org/10.1371/journal.pone.0113639

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