Cytoskeletal confinement of CX(3)CL1 limits its susceptibility to proteolytic cleavage by ADAM10

CX(3)CL1 is a unique chemokine that acts both as a transmembrane endothelial adhesion molecule and, upon proteolytic cleavage, a soluble chemoattractant for circulating leukocytes. The constitutive release of soluble CX(3)CL1 requires the interaction of its transmembrane species with the integral me...

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Detalles Bibliográficos
Autores principales: Wong, Harikesh S., Jaumouillé, Valentin, Heit, Bryan, Doodnauth, Sasha A., Patel, Sajedabanu, Huang, Yi-Wei, Grinstein, Sergio, Robinson, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244198/
https://www.ncbi.nlm.nih.gov/pubmed/25253723
http://dx.doi.org/10.1091/mbc.E13-11-0633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244198/
https://www.ncbi.nlm.nih.gov/pubmed/25253723
http://dx.doi.org/10.1091/mbc.E13-11-0633

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